Description: This product is colorless transparent micro mucus in the body. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. The steroids in this class include halcinonide. Halcinonide is designated chemically as 21-Chloro-9-fluoro-11β,16α,17-trihydroxypregn-4-ene-3,20-dione cyclic 16,17-acetal .
Pharmacological effects: This product is topical corticosteroids efficient fluorine and chlorine, with anti-inflammatory, anti- itching and vasoconstriction. This product is in the skeleton of triamcinolone, the chlorine atom instead of 21 hydroxy, the vasoconstriction test determination of anti-inflammatory potency multiples of 360, there is evidence that the intensity and efficacy of vasoconstriction test is consistent. Antipruritic mechanism of anti-inflammatory β receptor protocatechuic acid-amine reaction, through the activation of adenylate cyclase CAMP generate increased phosphoric acid ethyl ester and inhibit the enzyme CAMP destruction reduce the results of cAMP in the cells concentration increased, while inhibition of the release of histamine. This product inhibition granulomatous hyperplasia in rats and mice the role of dexamethasone similar. Swelling was observed, caused by formaldehyde in mice and rats after the heel of the goods and dexamethasone significantly inhibited, with five times the amount of hydrocortisone had no inhibitory effect. The product of the thymus and spleen have a significant role in weight loss.
reduce T lymphocytes, monocytes, the number of eosinophils, inhibition of lymphocyte proliferation and cytokine production, inhibition of macrophage differentiation and phagocytic activity , inhibition of neutrophil adhesion, reducing the permeability of endothelial cells, inhibition of fibroblast proliferation and collagen synthesis, inhibiting the activity of sebaceous gland cells.This product has anti-mitotic effect, which reduces the transcription of DNA, thereby reducing the synthesis of DNA, but also affect the dna repair, resulting in epidermal thinning, especially for the synthesis of collagen the greatest impact .The product of the corticosteroid receptor through the cytoplasm combined with a series of reactions occurs, activate the expression of cell lysis gene "; it induced nuclear lymphocytes dna cleavage direct cytotoxic lymphocyte death.
Pharmacokinetics: matrix formulations, epidermal barrier integrity and packet such as a variety of factors outside FDA percutaneous absorption. Can be absorbed through normal intact skin, inflammatory skin or other skin percutaneous absorption increase. Percutaneous absorption, the pharmacokinetic behavior and system applications, and different degrees of plasma protein binding, mainly hepatic metabolism and excretion from the kidney, but also some biliary excretion.
Indications: contact eczema, atopic dermatitis, neurodermatitis, the small size of psoriasis lichen planus, discoid lupus erythematosus, seborrheic dermatitis (facial), hypertrophic scars. dosage
Precautions: The primary skin lesions caused by bacteria, fungi, viruses and parasites. Ulcerative lesions. Acne, rosacea. eyelid drug (dangerous) caused by glaucoma. Exudative dermatitis. The face should not be applied. large area of a lot of medication or packet allows the percutaneous absorption can occur in systemic reactions, especially young children and infants, there may be retrograde cushing levy and growth retardation, sudden withdrawal acute adrenal insufficiency. Partial tolerance phenomenon, and should be discontinued and look for the causes. Vigilance to stay in the skin folds and diaper drug can be absorbed into the body.human no topical teratogenic effects during pregnancy should be used with caution. The excretion topical skin absorb large amounts of milk, lactation caution. should be a small area, short-term application, once subsided rapid withdrawal or switch to other drugs, children less than one year old as far as possible do not use this drug.
Adverse reaction: small number of patients with drug-coated parts of the skin occurred burning sensation, tingling, temporary itching, long-term application of skin telangiectasia (especially facial), skin atrophy, stretch marks (young people prone) skin atrophy secondary to purpura, petechiae, skin fragility, hirsutism, folliculitis, milia, skin discoloration, delay ulcer healing, packet easy to fungal infection in skin folds. Absorbed through the skin for a long time, the occurrence of systemic adverse reactions .
